C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/12 (2006.01) A61K 31/35 (2006.01) A61K 31/382 (2006.01) A61K 31/4025 (2006.01) A61K 31/4436 (2006.01) A61K 31/5377 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07C 233/00 (2006.01) C07D 209/20 (2006.01) C07D 213/40 (2006.01) C07D 215/42 (2006.01) C07D 311/68 (2006.01) C07D 335/06 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2522805
The present invention relates to compounds of formula (I): useful in treating Alzheimer~s disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer~s disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
La présente invention concerne des composés représentés par la formule (I): qui sont utiles pour le traitement de la maladie d'Alzheimer et autres maladies analogues. Ces composés renferment des inhibiteurs de l'enzyme bêta-secrétase enzyme qui sont utiles pour le traitement de la maladie d'Alzheimer et autres maladies analogues caractérisées par des dépôts de peptides A bêta chez un mammifère. Les composés de l'invention conviennent également pour des compositions et des méthodes thérapeutiques visant à réduire la formation de peptides A bêta.
Aquino Jose
Hom Roy
Pulley Shon
Tenbrink Ruth
Tucker John A.
Elan Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
Pharmacia & Upjohn Company Llc
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