Phenanthrolinedicarboxylate esters, 4-aminoquinoline and...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/12 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2002414

ABSTRACT A method for treating a human patient afflicted with human immunodeficiency virus comprising administering to such patient an effective amount of a compound of formula IA Image IA wherein R, R1 and R2 are as defined in the specification, e.g., dimethyl 1,4,7,10-tetrahydro-4,10-dioxo-6-(n-pentyl)-1,7-phenanthro- line-2,8-dicarboxylate; a compound of formula IB Image IB ,e.g., 1-benzoyl-4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl- piperazine, and salts thereof such as the maleate salt are described; a compound of formula IC Image IC ,e.g., 4-[(7-chloro-4-quinolyl)amino]-.alpha.-[[4-[(6-methoxy-8-quinolyl)- amino]pentyl]amino]-.alpha.'-1-pyrrolidinyl-2,6-xylenol trihydrochloride , and a compound of Formula ID Image ID ,e.g., 2'-[(5,5-dimethoxy-1-isoquinolyl)methyl]-4',5'-dimethoxyacetophenone.

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