Phenethanolamines and uses thereof

Details Phenethanolamines and uses thereof Phenethanolamines and uses thereof

C - Chemistry, Metallurgy

07

D

167/240, 260/319

C07D 209/14 (2006.01)

Patent

CA 1235705

PHENETHANOLAMINES AND USES THEREOF ABSTRACT OF THE DISCLOSURE New compositions using particular B2 agonists and vehicle materials have been prepared and are useful for producing a topical anti-inflammatory effect in mammals. The selected B2 agonists have previously not been known to exhibit topical anti- inflammatory activity. The compositions can be for example in the form of sprays, ointments, creams, gels, lotions, and suppositories, all of which are to be applied to the mammal topically, as opposed to systemically. Also, N-(3-Indolyl-isopropyl)- and N-(3-indolyl-t- butyl)-2-(4-hydroxy-3-methanesulfonamidophenyl)-2- hydroxyethylamines and their pharmaceutically accept-. able salts are antiasthmatic agents as demonstrated by bronchodilation action and inhibition of smooth muscle contraction caused by antigen-induced release of chemical mediators.

524032

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