C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/233, 167/246
C07C 323/62 (2006.01) A61K 31/19 (2006.01) C07C 317/44 (2006.01) C07C 323/20 (2006.01) C07C 323/22 (2006.01) C07C 323/25 (2006.01) C07C 323/52 (2006.01) C07C 323/65 (2006.01) C07C 327/22 (2006.01) C07C 331/10 (2006.01) C07D 257/04 (2006.01)
Patent
CA 1302424
Case 2441/1 ABSTRACT The compounds of the present invention comprise substituted phenolic thioethers represented by the formula: Image (I). wherein: R1 and R2 are the same or different and independently represent tert-alkyl or phenyl; A represents methylene or methylene substituted by alkyl, dialkyl or hydroxy, provided that when A includes hydroxymethylene, the hydroxymethylene group is not adjacent to a heteroatom; B represents sulfur, sulfoxide, sulfone, oxygen, -NH- or nitrogen substituted by alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl; C represents methylene or methylene substituted by alkyl; R3 represents CO2H, CO2-alkyl or a tetrazole group; m is 0 or 1, n is 2, 3 or 4 and p is 1, 2 or 3; and the pharmaceutically acceptable salts thereof. The compounds of the present invention are specific inhibitors of 5-lipoxygenase and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-1ipoxygenase metabolic pathway are involved.
528522
Deason James Ronald
Mueller Richard August
Partis Richard Allen
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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