Phenothiazine derivatives and a process for the preparation...

Details Phenothiazine derivatives and a process for the preparation... Phenothiazine derivatives and a process for the preparation...

C - Chemistry, Metallurgy

07

D

260/243.5

C07D 417/06 (2006.01) C07D 279/28 (2006.01) C07D 295/14 (2006.01)

Patent

CA 1128940

ABSTRACT OF THE DISCLOSURE The invention relates to new esters of 2-trifluoro- methyl-10[3-4-/2-hydroxyethyl/-piperazinyl-1)-propyl]-pheno- thiazine and pharmaceutically acceptable acid addition salts of these esters, furthermore to a process for the preparation of the new compounds. The acylating agents used in the prepara- tion of the esters are substituted or unsubstituted phenoxy- or naphthoxyisobutyric acids and functional derivatives there- of capable of forming an ester. 2-(6-Methoxy-2-naphthyl)- propionic acid and its functional derivatives can also be applied as acylating agents. The new compounds according to the invention possess valuable neuroleptic effects. The oily solutions of the free bases exert protracted effects when administered as an injec- tion. The biological activities of the new compounds are more favorable than those of the known flufenazine decanoate and flufenazine, respectively.

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