Phenotype prediction

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2650443

Detection of epigenetic alteration, especially methylation, of a gene or a combination of genes, preferably in a perinatal tissue sample such as umbilical cord, for predicting diverse phenotypic characteristics such as propensity for obesity, altered body composition, impaired cognition, low bone mineral content, neuro-behavioural problems and altered cardiovascular structure and function occurring in an individual.

La détection d'altération épigéniques spécialement de méthylation, d'un gène ou d'une combinaison de gènes, de préférence dans des échantillons de tissus périnataux par exemple du cordon ombilical permet de détecter certaines caractéristiques phénotypiques telles que la propension à l'obésité, une composition modifiée du corps, un déficit de cognition, une faible teneur des os en minéraux, des problèmes neuro-comportementaux, et une altération de la structure et des fonctions cardiovasculaires.

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