Phenotypic screen of chimeric proteins

C - Chemistry – Metallurgy – 12 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C12N 5/00 (2006.01) C12N 5/04 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2469477

In one aspect, a library of nucleic acids that encode different artificial, chimeric proteins is screened to identify a chimeric protein that alters a phenotypic trait of a cell or organism. The chimeric protein can be identified without a priori knowledge of a particular target gene or pathway. Some chimeric proteins include multiple zinc finger domains and can induce, for example, thermotolerance, solvent-tolerance, altered cellular growth, insulin production, differentiation, and drug resistance.

Un mode de réalisation de l'invention concerne une banque d'acides nucléiques codant diverses protéines artificielles chimériques qui est balayée de manière à identifier une protéine chimérique modifiant un caractère phénotypique d'une cellule ou d'un organisme. La protéine chimérique peut être identifiée sans connaissances <i>a</i> <i>priori</i> d'un gène cible particulier ou d'une voie cible particulière. Quelques protéines chimériques comprennent plusieurs domaines de doigt de zinc et peuvent induire, par exemple, une thermotolérance, une tolérance au solvant, une croissance cellulaire modifiée, une production d'insuline, une différentiation et une résistance aux médicaments.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Phenotypic screen of chimeric proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenotypic screen of chimeric proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenotypic screen of chimeric proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1596576

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.