Phenoxathiin derivatives as inhibitors of monoamine oxidase

Details Phenoxathiin derivatives as inhibitors of monoamine oxidase Phenoxathiin derivatives as inhibitors of monoamine oxidase

C - Chemistry, Metallurgy

07

D

C07D 327/00 (2006.01) C07D 327/08 (2006.01)

Patent

CA 2265943

Compounds of formula (I) wherein n is 0, 1 or 2; R1 is a branched or straight chain C1-5 alkyl or C3-6 cycloalkyl optionally substituted with hydroxyl, or one or more halogens, especially fluorine; and X1, X2, X3, X4, and X5 are either all hydrogens or one or two of X1, X2, X3, X4, and X5 are halogen and the remainder are hydrogens. These compounds inhibit monoamine oxidase-A and are useful in the treatment of disorders such as depression.

La présente invention concerne des composés représentés par la formule générale (I). Dans cette formule générale (I), n est un entier valant 0, 1 ou 2. R?1¿ est une chaîne alkyl en C1-5 droite ou ramifiée ou un cycloalkyl en C3-6 éventuellement substitué par un hydroxyl ou un ou plusieurs halogènes, et plus particulièrement le fluor. X?1¿, X?2¿, X?3¿, X?4¿ et X?5¿ sont, soit tous hydrogène, soit pour un ou deux des X?1¿, X?2¿, X?3¿, X?4¿ et X?5¿ un ou des halogènes, le reste étant des hydrogènes. Ces composés, qui sont des inhibiteurs de la monoamine oxydase-A, conviennent particulièrement au traitement de troubles tels que les dépressions.

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