Phenoxazine analogs useful as amyloid aggregation inhibitors...

Details Phenoxazine analogs useful as amyloid aggregation inhibitors... Phenoxazine analogs useful as amyloid aggregation inhibitors...

C - Chemistry, Metallurgy

07

D

C07D 265/38 (2006.01) A61B 5/055 (2006.01) A61K 31/538 (2006.01) A61K 49/10 (2006.01) A61K 51/08 (2006.01) A61P 25/28 (2006.01) C07D 265/34 (2006.01)

Patent

CA 2357450

Disclosed are compounds of the Formula I (see formula I) wherein: R1 is hydrogen, lower alkyl, or cycloalkyl; R2 is hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, aryl, heteroaryl, arylalkyl, heteroarylalkyl, arylalkoxy, heteroarylalkoxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, or mono- or dialkylamino; and R3 and R4 independently are hydrogen, lower alkoxy, aryl, heteroaryl, halogen, hydroxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, mono- or dialkylamino, or unsubstituted or substituted lower alkyl or lower alkenyl; or R3 and R4 together form an unsubstituted or substituted carbocyclic group. Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula I and a method of imaging amyloid deposits.

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