C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 59/74 (2006.01) A61K 31/19 (2006.01) C07C 45/68 (2006.01) C07C 47/575 (2006.01) C07C 69/712 (2006.01)
Patent
CA 2227691
This invention relates to 4-formyl-2-(naphthalenylmethyl)phenoxyacetic acids and pharmaceutically acceptable salts thereof according to formula (I), pharmaceutically compositions thereof, a method of treating hyperglycemia due to non-insulin dependent diabetes mellitus, and a method of prevention or treatment of complications associated with diabetes. In said formula the group A is selected from the group consisting of 1-naphthyl, 2-naphthyl, optionally substituted with alkyl of from one to six carbon atoms, fluorine, chlorine, bromine, iodine, trifluoromethyl, alkoxy of from one to six carbon atoms; R1 is hydrogen or alkyl of from one to six carbon atoms; R2 is selected from hydrogen, fluorine, chlorine, bromine, iodine, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms, and hydroxyl; or a pharmaceutically acceptable metal salt thereof.
Acides 4-formyl-2-(naphtalénylméthyl)phénoxyacétiques et leurs sels pharmaceutiquement acceptables, de formule (I), ainsi que compositions pharmaceutiques contenant lesdites substances, procédé de traitement de l'hyperglycémie due au diabète sucré non insulino-dépendant et procédé de prévention ou de traitement des complications associées au diabète. Dans la formule (I), le groupe A est choisi dans le groupe constitué par 1-naphtyle, 2-naphtyle, éventuellement substitués par alkyle ayant un à six atomes de carbone, fluor, chlore, brome, iode, trifuorométhyle et alcoxy ayant un à six atomes de carbone; R?1¿ est hydrogène ou alkyle ayant un à six atomes de carbone; R?2¿ est choisi parmi hydrogène, fluor, chlore, brome, iode, alkyle ayant un à six atomes de carbone, alcoxy ayant un à six atomes de carbone, et hydroxyle. La présente invention concerne en outre un sel métallique pharmaceutiquement acceptable de ladite substance.
Gunawan Iwan
Malamas Michael Sotiorios
American Home Products Corporation
Ridout & Maybee Llp
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