Phenoxy-amino-propanols

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 317/54 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/165 (2006.01) A61K 31/36 (2006.01) C07C 217/32 (2006.01) C07D 317/06 (2006.01) C07D 317/58 (2006.01)

Patent

CA 1110253

ABSTRACT OF THE DISCLOSURE New phenoxy-amino-propanols and the physiologically acceptable acid addition salts thereof are provided herein. They have the formula Image wherein R1 is alkenyl, alkynyl, alkoxyalkyl or alkenyloxyalkyl with 2 - 6 C atoms in each case or cycloalkyl with 3 - 8 C atoms; and R2 is alkyl or hydroxyalkyl with 1 - 6 C atoms in each case, cycloalkyl with 3 - 8 C atoms, aralkyl or aralkyl wherein the aryl radical is mono- to tri-substituted by alkyl, alkoxy, OH, F and/or Cl or mono-substituted by methylenedioxy, with a total of 7 - 15 C atoms in each case. Preferred compounds are those where R1 is allyl, 2-methoxyethyl, 2-isopropoxyethyl or 2-allyloxyethyl and where R2 is 2-(3,4-dimethoxyphenyl)-ethyl, tert- butyl, or isopropyl. These compounds exhibit various pharmacological properties including isoprenaline-antagonism on the heart rate and blood pressure.

288332

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