Phenoxy-piperidines for the treatment of diseases such as...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 211/46 (2006.01) A61K 31/445 (2006.01)

Patent

CA 2473409

The invention relates to compounds of formula (1), wherein R1, R2', R2'', R2''', R3 and n are defined as per claim 1. Said compounds are effectors of the nicotinic and/or muscarinic acetylcholine receptor and are suitable for the prophylaxis or treatment of schizophrenia, depression, panic attacks, dementia, Alzheimer's disease, Lewy body dementia, neurodegenerative diseases, Parkinson's disease, Huntington's chorea, Tourette's syndrome, learning limitations and memory loss, senile mnemasthenia, for relieving withdrawal symptoms in nicotine dependency, or for the prophylaxis or treatment of cerebral apoplexy or cerebral damage caused by toxic compounds.

L'invention concerne des composés de formule (I), dans laquelle R?1¿, R?2¿', R?2¿'', R?2¿''', R?3¿ et n ont les significations indiquées dans la revendication n·1. Ces composés sont des effecteurs du récepteur nicotinique et/ou muscarinique de l'acétylcholine et sont adaptés pour prévenir ou traiter les affections et troubles suivants : schizophrénie, dépression, états d'anxiété, démence, maladie d'Alzheimer, démence à corps de Lewy, maladies neurodégénératives, maladie de Parkinson, chorée de Huntington, syndrome de Tourette, problèmes d'apprentissage et de mémoire, pertes de mémoire dues à l'âge, accident vasculaire cérébral et lésions cérébrales occasionnées par des composés toxiques. Ils peuvent être utilisés également pour soulager des états de manque liés à une dépendance à la nicotine.

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