Phenoxyacetic acid derivatives

Details Phenoxyacetic acid derivatives Phenoxyacetic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 59/70 (2006.01) A61K 31/195 (2006.01) A61K 31/395 (2006.01) C07C 59/68 (2006.01) C07C 69/712 (2006.01) C07C 69/734 (2006.01) C07C 235/34 (2006.01) C07C 235/38 (2006.01) C07C 235/78 (2006.01) C07C 239/20 (2006.01) C07C 243/32 (2006.01) C07C 251/16 (2006.01) C07C 251/40 (2006.01) C07C 251/86 (2006.01) C07C 255/37 (2006.01) C07C 259/06 (2006.01) C07C 259/14 (2006.01) C07C 311/27 (2006.01) C07D 213/53 (2006.01) C07D 213/55 (2006.01) C07D 231/12 (2006.01) C07D 249/04 (2006.01) C07D 261/08 (2006.01) C07D 263

Patent

CA 2090283

Abstract We proposed a novel compound having an activity of PGI2 receptor agonist. A phenoxyacetic acid derivative of the formula Image A is -C(R1)=N-OR2, -CH(R)NH-OR2, -COE, -SO2E, -CH2-NR3-Y, -Z- NR3-CONR4R5, -CH2-OR6, -CO2R6, -CH2-O-N=CR7R8, -CH2-O-NHCHR7R8, substituted by imidazolyl(methyl), pyrazolylmethyl, oxazolyl(methyl), thioxazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolylmethyl; T is alkylene, alkenylene, etc.; D is-CO2R10,-CONR11R12; E is (substitution) amino, hydradino; Y is substituted (thio) carbonyl, substituted sulfonyl; Z is-CH=N-, -CH2NR3-; R1, R3, R10-R13 is each H or alkyl, etc.; R2, R4-R9 is each H, alkyl or alkyl substituted by phenyl or hetero ring, etc. and non-toxic salts thereof, non-toxic acid addition salts thereof, possess an agonistic on PGI2 receptor, so it is useful for prevention and/or treatment of thrombosis, arteriosclosis, ischemic heart diseases, gastric ulcer and hypertension. 151

Affiliated with

Also associated with

Rating

Phenoxyacetic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenoxyacetic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenoxyacetic acid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1818841