Phenoxyacetic acid derivatives and preparation thereof

Details Phenoxyacetic acid derivatives and preparation thereof Phenoxyacetic acid derivatives and preparation thereof

C - Chemistry, Metallurgy

07

C

167/252, 167/260

C07C 311/19 (2006.01) A61K 31/195 (2006.01) C07C 311/15 (2006.01) C07C 311/29 (2006.01)

Patent

CA 1277675

Abstract: The present invention is directed to novel phenoxyacetic acids of the formula: Image (I) wherein Ring A is a phenylene group or a phenylene group having 1 or 2 substituents selected from a lower alkyl group, a lower alkoxy group and a halogen atom; either one or two groups of R1, R2, R3 and R4 are a lower alkyl group, and the other groups are hydrogen atoms; R5 is a phenyl group or a phenyl group having 1 to 3 substituents selected from a lower alkyl group, a halogen atom, a lower alkoxy group, a trihalogenomethyl group, and a nitro group; and -COOR6 is a carboxyl group or a protected carboxyl group, or pharmaceutically accept- able salts thereof. The compounds of formula (I) and salts thereof have potent platelet aggregation-inhibiting activity.

543552

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