C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/233, 167/246
C07C 311/19 (2006.01) A61K 31/195 (2006.01) A61K 31/395 (2006.01) C07C 311/17 (2006.01) C07C 311/51 (2006.01) C07C 323/67 (2006.01) C07D 207/16 (2006.01) C07D 233/64 (2006.01)
Patent
CA 2032570
ABSTRACT The present invention provides compounds of the general formula :- Image (I) in which the sulphonylaminoalkyl radical is in the ortho-, meta- or para-position to the phenoxyalkyl- carbonamide radical and in which R1 is an aryl, aralkyl or aralkenyl radical, the aryl moiety of which can, in each case, be substituted one or more times by halogen, cyano, alkyl, trifluoromethyl or alkoxy, R2 is a hydrogen atom or an alkyl or acyl radical, R3 and R4, which can be the same or different, are hydrogen atoms or lower alkyl radicals, n is 1, 2 or 3, R6 is a hydrogen atom or an alkyl radical containing 1 to 4 carbon atoms which is optionally terminally substituted by carboxyl, aminocarbonyl or alkoxycarbonyl, by alkylthio, hydroxyl, phenyl or by imidazol-4-yl and R5 is a hydrogen atom or, together with R6, forms an alkylene chain containing 3-or 4 carbon atoms, as well as the physiologically acceptable salts, esters, amides and optical isomers thereof; the compounds may be used in the treatment of heart and circulatory diseases.
Doerge Liesel
Stegmeier Karlheinz
Witte Ernst-Christian
Doerge Liesel
Stegmeier Karlheinz
Swabey Ogilvy Renault
Witte Ernst-Christian
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