Phenoxyalkylcarboxylic acid derivatives

Details Phenoxyalkylcarboxylic acid derivatives Phenoxyalkylcarboxylic acid derivatives

C - Chemistry, Metallurgy

07

C

167/254, 167/262

C07C 59/90 (2006.01) A61K 31/19 (2006.01) C07C 69/76 (2006.01) C07D 303/24 (2006.01)

Patent

CA 1247126

ABSTRACT There are described novel pharmaceutically active com- pounds which, particularly, are antagonists of slow reac- ting substance of anaphylaxis (SRS-A) and thus are useful as agents in the treatment of allergic conditions. These compounds can be depicted by the general formula Image wherein R is hydrogen or lower alkyl, R1 is hydrogen or lower alkyl, R2 is lower alkanoyl, R3 is hydrogen or methyl, R4 is hydrogen or lower alkyl, R5 is hydrogen, halogen, lower alkyl or lower alkanoyl, Z is lower alkylene, 2-hydroxypropylene or the group -(CH2)s?O(CH2)s?t, s is the integer 2, 3 or 4 t is the integer 1, 2 or 3 and n is an integer from 1 to 7, and, when R4 is hydrogen, salts thereof with pharmaceuti- cally acceptable bases.

425448

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