Phenoxyethylamine derivatives, process for preparing the...

Details Phenoxyethylamine derivatives, process for preparing the... Phenoxyethylamine derivatives, process for preparing the...

C - Chemistry, Metallurgy

07

D

167/208, 167/267

C07D 295/22 (2006.01) A61K 31/18 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07C 311/27 (2006.01) C07C 311/37 (2006.01) C07D 295/26 (2006.01)

Patent

CA 1326667

ABSTRACT OF THE DISCLOSURE Phenoxyethylamine derivatives represented by the general formula (I): Image (I) wherein R1 and R5 represent lower-alkyl, R2 and R3, which may be the same or different, each represents hydrogen or lower-alkyl, or Image represents a 5- or 6-membered ring system which may include nitrogen, oxygen or sulfur as a ring membered atom, R4 represents hydrogen or lower-alkyl, and n represents an integer selected from 1 to 3, their optical isomers and pharmacologically-acceptable acid addition salts, which exhibit excellent .alpha.1 blocking activity, a process for their preparation, pharmaceutical compositions thereof; and a method for the treatment of a subject afflicted with hypertension or dysuria by administrating such a compound, are all disclosed.

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