C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 317/54 (2006.01) A61K 31/36 (2006.01) C07C 65/24 (2006.01) C07D 317/56 (2006.01) C07D 317/58 (2006.01) C07D 317/60 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2195758
Phenoxyphenylacetic acids and derivatives of general structural formula (I) have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.
Acide phénoxyphénylacétique et ses dérivés de formule générale (I) présentant une activité antagoniste de l'endothéline, et s'avérant utiles dans le traitement des troubles cardio-vasculaires tels que l'hypertension, l'insuffisance rénale postischémique, les angiospasmes, les ischémies cérébrales et coronarienne, l'infarctus du myocarde, le choc endotoxique, l'adénome prostatique, certains troubles inflammatoires dont la maladie de Raynaud et l'asthme.
Bagley Scott W.
Broten Theodore P.
Chakravarty Prasun K.
Dhanoa Daljit S.
Fitch Kenneth J.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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