((phenyl-4 piperazinylethyl)-2 anilino)-3 isobenzofuranones,...

Details ((phenyl-4 piperazinylethyl)-2 anilino)-3 isobenzofuranones,... ((phenyl-4 piperazinylethyl)-2 anilino)-3 isobenzofuranones,...

C - Chemistry, Metallurgy

07

D

260/266.7

C07D 405/12 (2006.01) C07D 307/90 (2006.01)

Patent

CA 1228071

-32- ABSTRACT OF THE DISCLOSURE This invention relates to ((phenyl-4 piperazinylethyl)-2 anilino)-3 isobenzofuranones, their method of preparation and their use in the treatment of conditions such as hypertension, and allergies. These compounds are characterized by the formula: Image in which R1 may be one or more substituents located at the ortho, meta, or para positions selected from the group of H, CH3, CF3, F, Cl and OCH3; R2 and R3 are the same or different and are H or OCH3. These compounds are in the form of free bases or their pharmaceutically safe salts. They can be obtained by a reaction between a (phenylpiperazinylethyl)-2 aniline and an aromatic aldehyde having an acid function at the ortho position of the carboxaldehyde function. These derivatives are useful for the treatment of hypertension and allergic conditions.

432970

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