Phenyl amino pyrimidine compounds and uses thereof

Details Phenyl amino pyrimidine compounds and uses thereof Phenyl amino pyrimidine compounds and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/444 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C07D 239/42 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2702650

The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

La présente invention concerne des composés de phénylamino pyrimidine qui sont des inhibiteurs des protéines kinases y compris des kinases JAK. Plus particulièrement les composés sont sélectifs contre les kinases JAK2. Les inhibiteurs des kinases peuvent être utilisés dans le traitement des maladies associées aux kinases telles que les maladies immunologiques et inflammatoires y compris les transplantations d'organe; les maladies hyperprolifératives telles que le cancer et les syndromes myéloprolifératifs; les maladies virales; les maladies métaboliques et les maladies vasculaires.

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