Phenyl butyl nitrone compositions for prevention of gastric...

Details Phenyl butyl nitrone compositions for prevention of gastric... Phenyl butyl nitrone compositions for prevention of gastric...

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/15 (2006.01)

Patent

CA 2077653

Compositions containing PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient, are disclosed for treating or preventing gastric ulceration caused by ingestion of non-steroidal anti-inflammatories. Based on animal studies, the dosage is in the range of 3 to 300 mg/kg and is administered prior to, simultaneously, or shortly after ingestion of the NSAID compound(s). In the preferred embodiment, the rangee is between 10 and 30 mg/kg, depending on the dosage unit required to protect the mucosa. The preferred method of administration is orally, alone or in combination with the non-steroidal anti-inflammatory. It is believed that the PBN is also useful alone for treatment or prevention of ulcers, aspects of diarrhea, gastritis, esophagitis, ileitis, and as an analgesic.

Compositions renfermant du PBN ou l'un de ses dérivés actifs dans un véhicule pharmaceutique approprié, administrées à un patient pour le traitement ou la prévention de l'ulcération gastrique causée par l'ingestion d'anti-inflammatoires non stéroïdiens. D'après des expériences avec des animaux, une dose de 3 à 300 mg/kg est administrée avant, pendant ou peu après l'ingestion du ou des composés de la DAINS. Dans la version privilégiée, la plage se situe entre 10 et 30 mg/kg, de façon à protéger la muqueuse. La méthode préférée d'administration est orale, seul ou en combinaison avec l'anti-inflammatoire non stéroïdien. On pense que le PBN est également utile seul pour la prévention ou le traitement des ulcères, de certains aspects de la diarrhée, de la gastrite, de l'oesophagite, de l'iléite, et enfin comme analgésique.

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