Phenyl-containing n-acyl amine and aminoacid derivatives,...

Details Phenyl-containing n-acyl amine and aminoacid derivatives,... Phenyl-containing n-acyl amine and aminoacid derivatives,...

C - Chemistry, Metallurgy

07

C

C07C 233/51 (2006.01) A61K 31/165 (2006.01) A61K 38/05 (2006.01) A61P 25/16 (2006.01) A61P 29/00 (2006.01) C07C 237/20 (2006.01) C07C 237/22 (2006.01) C07K 5/065 (2006.01)

Patent

CA 2602545

The invention relates to novel phenyl-containing N-acyl of biogenic amine and aminoacid derivatives of general formula (I) which are used in the form of analgesic and anti-inflammatory cyclooxygenase inhibitors devoid of side effects, in particular ulcerogenous and prospasmodic actions, have the ability of potentiating the action of other analgesics and exhibit an antihypoxic, antidepressant and antiparkinson activity, and to methods for producing novel and known phenyl-containing N-acyl biogenic amine derivatives, to a pharmaceutical composition and agent containing the formula (I) compounds and to the use thereof and a curing method.

La présente invention concerne de nouveaux dérivés N-acylés d'amines et d'acides aminés biogéniques contenant des phényles ayant la formule générale I (formule) utilisés en tant qu'inhibiteurs de cyclooxygénase possédant des propriétés analgésiques et anti-inflammatoires, sans effets secondaires tels que, notamment, les propriétés ulcérogènes ou prospasmatiques; ils ont en outre la capacité de potentialiser l'action d'autres analgésiques possédant également une action anti-hypoxiques, anti-dépressive et anti-Parkinson; l'invention concerne enfin des procédés de fabrication de dérivés N-acylés, nouveaux ou connus, d'amines et d'acides aminés biogéniques contenant des phényles, d'une composition pharmaceutique et un produit contenant des composés correspondant à la formule générale I ainsi qu'une utilisation et un procédé de traitement correspondants.

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