Phenyl derivatives and methods of use

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 275/32 (2006.01)

Patent

CA 2583297

Novel phenyl compounds, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the compounds are agonists and/or ligands of cannabinoid receptors and may be useful, inter alia, for treating and/or preventing pain, gastrointestinal disorders, genitourinary disorders, inflammation, glaucoma, auto-immune diseases, ischemic conditions, immune-related disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, and as an appetite stimulant.

L'invention concerne de nouveaux composés phényles, des compositions pharmaceutiques contenant lesdits composés, ainsi que leurs méthodes d'utilisation pharmaceutique. Dans certains modes de réalisation, les composés sont des agonistes et/ou des ligands de récepteurs cannabinoïdes et peuvent être utiles, entre autres, pour le traitement et/ou la prévention de la douleur, de troubles gastro-intestinaux, de troubles génito-urinaires, de l'inflammation, du glaucome, de maladies auto-immunes, de pathologies ischémiques, de troubles immunitaires et aux maladies neurodégénératives, pour assurer une cardioprotection contre les effets ischémiques et de reperfusion, pour induire une apoptose dans des cellules malignes, ainsi qu'en tant que stimulant d'appétit.

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