Phenyl hydroxamic acids including a hetero-containing...

Details Phenyl hydroxamic acids including a hetero-containing... Phenyl hydroxamic acids including a hetero-containing...

C - Chemistry, Metallurgy

07

C

167/246, 260/452

C07C 239/08 (2006.01) A61K 31/165 (2006.01) C07C 323/60 (2006.01)

Patent

CA 1304390

QA198 PHENYL HYDROXAMIC ACIDS INCLUDING A HETERO-CONTAINING SUBSTITUENT Phenyl hydroxamic acids are disclosed having the general formula Image or a pharmaceutically acceptable salt thereof, wherein X is NR, oxygen, sulfur, (?)g or a single bond, and Y is NR, oxygen, sulfur, (?)g or a single bond, where R can be hydrogen or lower alkyl, g can be 1 or 2, and with the proviso that at least one of X and Y is other than a single bond; Z is aryl, aralkyl or cycloalkyl; R1 is hydrogen, substituted or unsubstituted lower alkyl, cycloalkyl, lower alkenyl or aryl; R2 is hydrogen, QA198 lower alkyl, aroyl or acyl; m is 0 to 4 carbon atoms; and, n is 0 to 4 carbon atoms. These new compounds have been found to be inhibitors of arachidonic acid 5-lipoxygenase and are therefore useful as antiallergy agents and antipsoriatics.

551308

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