C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2723222
In its many embodiments, the present invention provides provides certain 2- imino-3-methyl pyrrolo pyrimidone compounds, including compounds Formula (II): and include tautomers, steroisomers, or pharmaceutically acceptable salts or solvates of said compounds, stereoisomers, or said tautomers, wherein R2, R3, R4, R5, R6, R7, R8, and R9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (A.beta.) protein, including Alzheimer's Disease, are also disclosed.
Dans ses nombreux modes de réalisation, la présente invention concerne certains composés de 2-imino-3-méthyl-pyrrolo pyrimidone, notamment des composés de formula (II) : (II), ainsi que des tautomères, des stéréo-isomères ou des sels ou solvates pharmaceutiquement acceptables de ces composés, stéréo-isomères ou tautomères, dans laquelle R2, R3, R4, R5, R6, R7, R8 et R9 sont sélectionnés indépendamment et sont tels que définis dans la description. Linvention concerne également des compositions pharmaceutiques contenant au moins un de ces composés, ainsi que des méthodes de préparation et dutilisation de ces compositions dans le traitement de pathologies associées à la protéine amyloïde bêta (Aß), notamment la maladie dAlzheimer.
Cumming Jared N.
Iserloh Ulrich
Li Guoqing
Liu Xiaoxiang
Mandal Mihirbaran
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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