Phenyl-substituted 2-thiazolyl tetrazolium salt indicators

Details Phenyl-substituted 2-thiazolyl tetrazolium salt indicators Phenyl-substituted 2-thiazolyl tetrazolium salt indicators

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) C07D 417/14 (2006.01) G01N 31/22 (2006.01) G01N 33/52 (2006.01)

Patent

CA 2049209

Phenyl-substituted 2-thiazolyl tetrazolium salt compounds characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

Dérivés de substitution phényliques de sels de 2-thiazolyltétrazolium, caractérisés par un spectre de réflectance présentant un palier élargi au dessus de 600-650 nm environ. Ces dérivés sont utiles comme indicateurs chromogènes pour la réduction de substances comme NADH. Le palier de réflectance donne une meilleure précision aux mesures analytiques, particulièrement pour le dosage de substances à analyser, importantes au niveau du diagnostic médical, dans lequel une réponse colorimétrique sur une matrice-véhicule de réactif est mesurée par réflectance.

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