C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/18 (2006.01) A61K 31/451 (2006.01) A61K 31/454 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2507465
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.
L'invention concerne des activateurs de PPAR alpha, des compositions pharmaceutiques contenant ces composés et l'utilisation de tels composés pour augmenter certains taux de lipides plasmatiques, y compris le cholestérol HDL, et diminuer certains taux d'autres lipides plasmatiques tels que le cholestérol LDL et les triglycérides, et traiter ainsi des maladies exacerbées par de faibles taux de cholestérol HDL et/ou des taux élevés de cholestérol LDL et de triglycérides, telles que l'athérosclérose et les maladies cardiovasculaires, chez des mammifères, y compris l'être humain.
Bagley Scott William
Brandt Thomas Andrew
Dugger Robert Wayne
Hada William Andrew
Hayward Cheryl Myers
Pfizer Products Inc.
Smart & Biggar
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