C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01) C07D 221/16 (2006.01)
Patent
CA 2293549
Novel phenyl-substituted tricyclic compounds of formula (1.0) and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N- substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
La présente invention concerne des composés tricycliques à substitution phényle de formule (1.0) et des compositions pharmaceutiques, lesquels sont inhibiteurs de l'enzyme farnésyle protéine transférase. La présente invention concerne également un procédé d'inhibition de la fonction Ras et donc d'inhibition de la croissance anormale des cellules. Le procédé consiste à administrer le nouveau composé d'urée à substitution halo-N à un système biologique. Ce procédé inhibe, en particulier, la croissance anormale des cellules chez des mammifères tel que l'homme.
Afonso Adriano
Kelly Joseph M.
Rosenblum Stuart B.
Weinstein Jay
Wolin Ronald L.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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