¬(phenyl-sulphamoyl or sulphonamido)-...

C - Chemistry – Metallurgy – 07 – D

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C07D 217/22 (2006.01) C07D 217/04 (2006.01)

Patent

CA 1296011

11932/11946 ABSTRACT The invention provides compounds of the formula (I): Image (I) and salts thereof; wherein A is a group NR3SO2 or SO2NR3: B is an acyclic hydrocarbon group having from one to six linear carbon atoms, provided that the carbon atom attached to the nitrogen atom is saturated: Y is CO2H or a group hydrolysable to CO2H; R1 is phenyl optionally substituted by one or more substituents chosen from the group comprising halogen, C1-4alkyl, C1-6acyl, C1-4alkoxy, nitro and trifluoromethyl; R2 is hydrogen or one or more C1-4alkyl substituents located at the 1, 3 and 4 positions of the isoquinoline ring: and R3 is hydrogen or C1-6alkyl. Also disclosed are pharmaceutical compositions containing the compounds, methods for making them and the use of the compounds as thromboxane A2 antagonists.

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