Phenylacetamide derivative

Details Phenylacetamide derivative Phenylacetamide derivative

C - Chemistry, Metallurgy

07

D

C07D 213/80 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/437 (2006.01) A61K 31/44 (2006.01) A61K 31/497 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01) C07D 231/40 (2006.01) C07D 241/20 (2006.01) C07D 277/20 (2006.01) C07D 277/46 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2712948

[Problems] To provide a compound which is useful as a GK activator. [Means for Solving Problems] The present inventors have conducted extensive studies on a phenylacetamide derivative, and as a result, have confirmed that a phenylacetamide derivative having sulfonyl group and cycloalkyl group on the phenyl group and having heteroaryl group on the nitrogen atom in the amide has an excellent GK activation action, thereby completing the present invention. The compound of the present invention is useful as an agent for treating diabetes, in particular, type II diabetes, since it has an excellent GK activation action.

L'invention porte sur un composé qui est utile comme activateur de GK. Des études approfondies sont faites sur des dérivés de phénylacétamide. Comme résultat, il est confirmé qu'un dérivé de phénylacétamide possédant un groupe sulfonyle et un groupe cycloalkyle sur un groupe phényle dans celui-ci et un groupe hétéroaryle sur un atome d'azote dans un amide dans celui-ci présente une bonne activité d'activation de GK. Le composé est utile comme agent thérapeutique pour le diabète, en particulier le diabète de type 2, étant donné que le composé présente une bonne activité d'activation de GK.

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