Phenylacetic acid compositions for treating or preventing...

A - Human Necessities – 61 – K

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A61K 31/198 (2006.01) A61K 31/192 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2345409

Pharmaceutical compositions effective in treating or preventing atherosclerosis and restenosis are disclosed. The pharmaceutical compositions of the present invention comprise one or more compounds selected from the group consisting of phenylacetic acid, pharmaceutically-acceptable salts thereof, pharmaceutically-acceptable precursors thereof, and pharmaceutically-acceptable analogs thereof (e.g., phenylacetylglutamine and iso-phenylacetylglutamine), suitably combined with appropriate carriers, diluents, or excipients. The compositions also optionally contain isoglutamine. Also disclosed are methods for treating or preventing atherosclerosis and restenosis by the administration of pharmaceutical compositions of the present invention.

Cette invention concerne des compositions pharmaceutiques efficaces dans le traitement ou la prévention de l'athérosclérose et de la resténose. Ces compositions consistent en au moins un composé choisi dans le groupe de l'acide phénylacétique, en ses sels, ses précurseurs, et ses analogues (par exemple la phénylacétylglutamine et l'iso-phénylacétylglutamine), tous les trois acceptables du point de vue pharmaceutique, associés à des véhicules appropriés, des diluants ou des excipients. Ces compositions peuvent éventuellement aussi contenir une isoglutamine. Cette invention concerne aussi des méthodes de traitement et de prévention de l'athérosclérose et de la resténose par administration des compositions pharmaceutiques de la présente invention.

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