Phenylacetic acid derivatives, process for the preparation...

Details Phenylacetic acid derivatives, process for the preparation... Phenylacetic acid derivatives, process for the preparation...

C - Chemistry, Metallurgy

07

C

C07C 229/42 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/22 (2006.01) A61K 31/24 (2006.01) C07C 53/10 (2006.01) C07C 69/66 (2006.01) C07C 211/54 (2006.01) C07C 227/18 (2006.01) C07C 229/40 (2006.01) A61K 31/19 (2006.01)

Patent

CA 2111169

The invention relates to phenylacetic acid derivatives, a process for the preparation thereof and corresponding use. These derivatives are identified by the following formula: Image where R1, R2 and R3 are the same or different and are a either methyl, ethyl or propyl radicals; or R2 and R3, which are attached as shown by -(R2....R3)-, jointly form a -(CH2)n- radical where n = 4 or 5, with the exception of the case where R1 = R2 = R3 = CH3, and also with the exception of the case where R1 = R3 = CH3 and R2 = ethyl; the process comprises the reaction of a diclofenac salt with the corresponding alkyl haloacetate of formula X-CH2-COO-CR1R2R3, (X = Cl or Br) in an homogenous medium. They are used for the preparation of [2-(2,6-dichloroanilino)phenyl]acetoxyacetic acid, by treatment with acids in an anhydrous medium. The derivatives have therapeutic activity as analgesics or anti-inflammatories.

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