Phenylalamine derivatives as integrin inhibitors

Details Phenylalamine derivatives as integrin inhibitors Phenylalamine derivatives as integrin inhibitors

C - Chemistry, Metallurgy

07

C

C07C 311/06 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) C07C 311/14 (2006.01) C07C 311/19 (2006.01) C07C 317/48 (2006.01) C07C 323/63 (2006.01) C07D 207/34 (2006.01) C07D 213/81 (2006.01) C07D 231/40 (2006.01) C07D 233/88 (2006.01) C07D 235/30 (2006.01) C07D 257/04 (2006.01) C07D 277/46 (2006.01) C07D 307/68 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2259224

Compounds of formula (I) wherein X, Y, Z, R1, R2, R3 and R4 have the meaning stated in claim 1, with the proviso that at least one element chosen from the group X, Y, Z must be CH2, as well as their physiologically harmless salts, can be used as integrin inhibitors, particularly for prophylaxis and treatment of circulatory diseases, in case of thrombosis, heart infarct, coronary heart diseases, arteriosclerosis, osteoporosis, in pathological processes which are maintained or propagated by angiogenesis, and in tumor therapy.

Les composés de formule (I), dans laquelle X, Y, Z, R?1¿, R?2¿, R?3¿ et R?4¿ ont la signification donnée dans la revendication (1), à condition qu'au moins un élément choisi dans le groupe X, Y, Z soit CH¿2?, ainsi que leurs sels physiologiquement inoffensifs, peuvent être utilisés comme inhibiteurs de l'intégrine, en particulier pour la prophylaxie et le traitement de maladies du système circulatoire, en cas de thrombose, d'infarctus du myocarde, de maladie cardiaque coronarienne, d'artérioslérose, d'ostéoporose, lors de processus pathologiques qui sont maintenus ou propagés par angiogenèse, et également pour le traitement des tumeurs.

Affiliated with

Also associated with

Rating

Phenylalamine derivatives as integrin inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenylalamine derivatives as integrin inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenylalamine derivatives as integrin inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1365614