Phenylalanine derivatives as dipeptidyl peptidase inhibitors...

Details Phenylalanine derivatives as dipeptidyl peptidase inhibitors... Phenylalanine derivatives as dipeptidyl peptidase inhibitors...

A - Human Necessities

61

K

A61K 31/397 (2006.01) A61K 31/40 (2006.01) A61K 31/426 (2006.01) A61K 31/445 (2006.01) C07D 205/04 (2006.01) C07D 207/04 (2006.01) C07D 207/10 (2006.01) C07D 207/16 (2006.01) C07D 277/04 (2006.01) C07D 295/185 (2006.01) C07D 295/192 (2006.01)

Patent

CA 2508487

The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase- IV enzyme is involved.

La présente invention concerne des dérivés de phénylalanine qui sont inhibiteurs de l'enzyme IV de dipeptidylpeptidase ("inhibiteurs IV DP") et qui sont utiles dans le traitement ou la prévention de maladies impliquant l'enzyme IV de dipeptidylpeptidase, telles que les diabètes et notamment le diabète de type 2. L'invention concerne également des compositions pharmaceutiques contenant ces composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement de telles maladies impliquant l'enzyme IV de dipeptidylpeptidase.

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