C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/81 (2006.01) A61P 37/00 (2006.01) C07C 229/36 (2006.01) C07C 229/46 (2006.01) C07C 233/82 (2006.01) C07C 323/30 (2006.01) C07D 213/89 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2434666
Phenylalanine enamide derivatives of formula (1) are described: wherein R1, RX, RY, RZ, X and V are as defined in claim 1. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
L'invention concerne des dérivés de phénylalanine-énamide de la formule (1): où R?1¿, R?X¿, R?Y¿, R?Z¿, X et V ont la définition donnée dans la revendication 1. Ces composés permettent d'inhiber la liaison des intégrines à leurs ligands et sont utilisés pour prévenir et traiter des troubles immunitaires ou inflammatoires ou des troubles impliquant la croissance inappropriée ou la migration de cellules.
Bailey Stuart
Brand Stephen
Brown Julien Alistair
Head John Clifford
Johnson James Andrew
Celltech R&d Limited
Kirby Eades Gale Baker
Ucb Pharma S.a.
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