Phenylalanine-glycine derivatives, process for preparation...

Details Phenylalanine-glycine derivatives, process for preparation... Phenylalanine-glycine derivatives, process for preparation...

C - Chemistry, Metallurgy

07

K

C07K 5/065 (2006.01) A61K 38/05 (2006.01) A61K 47/48 (2006.01) C07C 271/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2091316

PHENYLALANINE-GLYCINE DERIVATIVES PROCESS FOR PREPARATION THEREOF. AND PHARMACEUTICAL COMPOSITION CONTAINING SAID DERIVATIVES ABSTRACT OF THE DISCLOSURE A phenylalanine-glycine derivative of the general formula (I): Image (I) wherein R represents a residue of an antitumor substance, or a salt or ester thereof, a process for preparation thereof, and a pharmaceutical composition containing the same are described. The novel conjugate of the phenylalanine-glycine derivative and the antitumor substance exhibits superior antitumor activity in comparison with the case wherein an antitumor substance is administered singly or as a mixture with phenylalanine.

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