Phenylalkan (en)oic acids

Details Phenylalkan (en)oic acids Phenylalkan (en)oic acids

C - Chemistry, Metallurgy

07

C

167/208, 167/256

C07C 59/68 (2006.01) A61K 31/195 (2006.01) A61K 31/395 (2006.01) C07C 59/52 (2006.01) C07C 59/64 (2006.01) C07C 59/90 (2006.01) C07C 205/34 (2006.01) C07C 205/56 (2006.01) C07C 233/54 (2006.01) C07C 233/81 (2006.01) C07C 235/16 (2006.01) C07C 235/20 (2006.01) C07C 235/34 (2006.01) C07C 235/42 (2006.01) C07C 235/78 (2006.01) C07C 311/21 (2006.01) C07C 311/48 (2006.01) C07C 323/19 (2006.01) C07C 405/00 (2006.01) C07D 207/27 (2006.01) C07D 209/08 (2006.01) C07D 209/48 (2006.01) C07D 275/03 (2006.01) C07D 277/4

Patent

CA 2019335

The phenylalkan(en)oic acids of the formula: Image wherein A is i) ~NHCO~, ii) ~O~ iii) ~NHSO2~, iv) ~CO~ v) ~CH2~ or vi) ~CH(OH)~; W is ~i) C1-13 alkylene, ii) phenylene or iii) Image ; R is ~i) hydrogen, ii) C1-4 alkyl, iii)~COOH, iv) saturated or unsaturated, 4-7 membered mono-cyclic hetero ring containing one nitrogen as a hetero atom or saturated or unsaturated, 4-7 membered mono-cyclic hetero ring containing one nitrogen as a hetero atom substituted by an oxo group, Image A, taken together with W and R1, is Image two R2 are, same or different, i) hydrogen, -2- ii) C1-4 alkyl or iii) 4-7 membered, saturated or unsaturated, mono-cyclic hetero ring containing two or three of nitrogen and sulfur in total, or two R2, taken together with a nitrogen to which they are attached, form saturated or unsaturated, i) 7-14 membered, bi-or tri-cyclic hetero ring containing one nitrogen as a hetero atom, or ii) 4-7 membered, mono-cyclic hetero ring containing two or three of nitrogen and oxygen in total ; Y is ethylene or vinylene; D is i) -Z-B II) Image or Z is C3-11 alkylene or alkenylene B is Image or Z, taken together with B, is C3-22 alkyl; R3 is i) hydrogen, ii) halogen, III) C1-8 alkyl, alkoxy or alkylthio, or iv) C2-8 alkenyl, alkenyloxy or alkenylthio; n is 1-3; R4 is C1-7 alkylene; R5 is i) C1-12 alkyl, ii) C2-12 alkenyl, iii) C5-7 cycloalkyl or iv) phenethyl or phenethyl wherein the ring is substituted by one C1-4 alkoxy; -3- Two R6 are, same or different, i) C1-7 alkyl, ii) benzyl or iii) phenyl or phenyl wherein the ring is substituted by one C1-4 alkyl; and Two R7 are, same or different, C1-4 alky; with the proviso that i) ~A~W~R1 should bind to 3- or 4- carbon in benzene ring, and Image ii) when W is phenylene or Image , A should not represent ~O~, ~CO~, ~CH2~ or ~CH(OH)~; and non-toxic salts thereof, possess an antagonism on leukotriene B4, and therefore, are useful for the prevention and treatment of several diseases induced by leukotriene B4.

Affiliated with

Also associated with

Rating

Phenylalkan (en)oic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenylalkan (en)oic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenylalkan (en)oic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1577458