Phenylalkanolamine derivatives

Details Phenylalkanolamine derivatives Phenylalkanolamine derivatives

C - Chemistry, Metallurgy

07

D

C07D 211/22 (2006.01) A61K 31/445 (2006.01) C07D 211/14 (2006.01)

Patent

CA 2129771

Compounds of the formula (see formula I) wherein R is hydrogen, hydroxy, or aryl lower alkyloxy; X is hydrogen; Y is hydroxy or hydrogen; or both X and Y taken together are oxygen; Z is aryl lower alkyl; and m is an integer from 1 to 4 or a diastereomer or an enantiomer thereof, except, the R,R diastereomer of formula I, wherein X is hydrogen, Y is hydroxy, R is benzyloxy, Z is benzyl, and m is 1, or pharmaceutically acceptable salts thereof, reduce adverse effects of toxic injury to central neurons and thus are useful in the treatment of ischemia, stroke, hypoxia and the like.

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