Phenylalkanoyl substituted imidazo {4,5-c} pyridines

Details Phenylalkanoyl substituted imidazo {4,5-c} pyridines Phenylalkanoyl substituted imidazo {4,5-c} pyridines

C - Chemistry, Metallurgy

07

D

167/231, 260/273

C07D 471/04 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2025202

8768N Abstract Phenylalkanoyl Substituted Imidazo[4,5-c]Pyridines This invention relates to substituted imidazopyridine dervatives having the following formula Image I and isomers thereof; or a pharmaceutically acceptable acid addition salt thereof: wherein Rl and R2 are each independently selected from hydrogen; straight or branched chain alkyl of 1 to 15 carbon atoms; cycloalkyl of 3 to 8 carbon atoms: substituted cycloalkyl which can be substituted one or more by alkyl of 1 to 6 carbon atoms: phenyl; 8768N substituted phenyl which can be substituted one or more by alkyl of 1 to 6 carbon atoms or halogen; straight or branched alkenyl having 3 to 15 carbon atoms. y is phenyl or phenyl substituted once or more than by alkyl of 1 to 6 carbon atoms; alkoxy wherein the alkyl is 1 to 6 carbon atoms; and halogen selected from the group consisting of bromo, fluoro or chloro. m is an integer from 0 to 5. n is an integer from 1 to 5. R3 is a group substituted at one or more of the 4, 6 or 7 positions of the pyridine ring said groups being independently selected from hydrogen, alkyl of l to 6 carbon atoms; halogen wherein the halogen is selected from bromo, fluoro, or chloro: 8768N or alkoxy wherein the alkyl is 1 to 6 carbon atoms; R4 is hydrogen or alkyl of 1 to 4 carbon atoms. useful in the treatment of diseases or disorders mediated by platelet-activating factor. This invention also relates to pharmaceutical compositions of such substituted imidazopyridines.

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