C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/245, 260/361
C07D 307/80 (2006.01) A61K 31/34 (2006.01) C07D 307/79 (2006.01) C07D 311/58 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)
Patent
CA 1308416
1760S/0977A 17143 TITLE OF THE INVENTION PHENYLALKYL-2,3-DIHYDROBENZOFURANS AND ANALOGS USEFUL AS ANTI-INFLAMMATORY AGENTS ABSTRACT OF THE INVENTION Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a cinnamylhalide followed by reduction; or (2) by Wittig reaction involving a halomethyl derivative of 2,3-dihydrobenzofuran (or 2,3-dihydrobenzopyran and an aryl or a heteroaryl aldehyde followed by reduc- tion. These compounds were found to be potent anti- inflammatory agents.
507263
Boulton David A.
Chang Michael N.
Thompson Kathryn L.
Boulton David A.
Chang Michael N.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Thompson Kathryn L.
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