Phenylalkyl derivatives, pharmaceutical compositions...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 215/48 (2006.01) A61K 31/395 (2006.01) C07D 209/08 (2006.01) C07D 215/14 (2006.01) C07D 215/18 (2006.01) C07D 215/22 (2006.01) C07D 215/227 (2006.01) C07D 215/36 (2006.01) C07D 215/38 (2006.01) C07D 217/06 (2006.01) C07D 223/16 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2288744

The invention relates to phenylalkyl derivatives of general formula (I) in which A, B, W, Y and Ra to Rd are as defined in claim 1, their tautomers, their stereoisomers, their mixtures and their salts with valuable properties. The compounds of general formula (I), in which Rb is a hydrogen atom, a nitro group or a cyano group, are valuable intermediates for producing the other compounds of general formula (I). Furthermore, the compounds having general formula (I), in which Rb is one of the optionally substituted aminomethyl or amidino groups mentioned in claim 1, as well as their tautomers and stereoisomers, have valuable pharmacological properties, in particular as thrombin inhibitors and in extending the thrombin time.

L'invention concerne des dérivés phénylalkylés de formule générale (I) dans laquelle A, B, W, Y et Ra à Rd sont tels que définis dans la revendication 1, leurs tautomères, leurs stéréoisomères, leurs mélanges et leurs sels présentant des propriétés de valeur. C'est ainsi que les composés de formule générale (I), pour lesquels Rb est un atome d'hydrogène, un groupe nitro ou un groupe cyano, constituent des produits intermédiaires de valeur pour la fabrication des autres composés de formule générale (I), et les composés de formule générale (I), pour lesquels Rb désigne l'un des groupes aminométhyle ou amidino éventuellement substitués, mentionnés dans la revendication 1, ainsi que leurs tautomères et leurs stéréoisomères présentent des propriétés pharmacologiques de valeur, en particulier un effet inhibiteur de thrombine et un effet prolongeant le temps de thrombine.

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