Phenylalkyl-imidazole-bisphosphonate compounds

Details Phenylalkyl-imidazole-bisphosphonate compounds Phenylalkyl-imidazole-bisphosphonate compounds

C - Chemistry, Metallurgy

07

F

C07F 9/6506 (2006.01) A61K 31/663 (2006.01)

Patent

CA 2746612

(Unsubstituted or substituted phenyl)-alkyl-substituted [(imidazol-1-yl)-1- hydroxy-1- phosphono-ethyl]-phosphonic, as well as methods or processes for their manufacture, their use in the manufacture of pharmaceutical formulations, their use in the treatment of diseases, methods of using them in the treatment of diseases, pharmaceutical formulations encompassing them and/or the compounds for use in the treatment of diseases, are disclosed. The compounds are able to inhibit excessive or inappropriate bone resorption. The compounds are of the formula (I), wherein one of R1 and R2 are as defined in the specification, and can be in free form, in the form of an ester, and/or of a salt.

L'invention porte sur des composés [imidazol-1-yl)-1-hydroxy-1-phosphonoéthyl]phosphoniques (phényl non substitué ou substitué)alkyl-substitués, ainsi que sur leurs procédés ou processus de fabrication, leur utilisation dans la fabrication de formulations pharmaceutiques, leur utilisation dans le traitement de maladies, des procédés d'utilisation de ceux-ci dans le traitement de maladies, des formulations pharmaceutiques les comprenant et/ou les composés destinés à être utilisés dans le traitement de maladies. Les composés sont aptes à inhiber une résorption osseuse excessive ou inappropriée. Les composés sont représentés par la formule (I), dans laquelle l'un de R1 et R2 est tel que défini dans la description, et peuvent être sous forme libre, sous la forme d'un ester et/ou d'un sel.

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