Phenylalkylamines, their preparation and their use as...

Details Phenylalkylamines, their preparation and their use as... Phenylalkylamines, their preparation and their use as...

C - Chemistry, Metallurgy

07

D

260/351, 260/602

C07D 317/58 (2006.01) C07D 295/135 (2006.01) G11B 23/087 (2006.01) G11B 25/06 (2006.01)

Patent

CA 1202636

ABSTRACT OF THE DISCLOSURE Compounds of general formula I ,(I) Image wherein R1 represents a hydroxy group or an optionally sub- stituted amino group; R2 and R3 each represents a halogen atom, a trifluoromethyl, cyano or nitro group or one of the radicals R2 or R3 represents a hydrogen atom; R4 represents a hydrogen atom or an alkyl group; R5 represents a hydrogen atom, an alkyl, cycloalkyl, alkenyl or aralkyl group; A re- presents a methylene, ethylene or hydroxymethylene group; and B represents an optionally substituted aralkyl group, whereby the methylene group adjacent to the phenyl nucleus, may be replaced by an oxygen or sulfur atom, or a sulfinyl or sulfonyl group; all optical isomers thereof, and mixtures of the aforesaid optical isomers; and acid addition salts thereof. Proceses for the preparation of the new compounds as well as pharmaceutical compositions containing them are also objects of this invention. The new compounds show valuable pharmacological properties, especially effects on the heart and circulation.

391831

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