C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/00 (2006.01) A61K 31/18 (2006.01) A61K 31/44 (2006.01) C07D 213/02 (2006.01)
Patent
CA 2548849
The present invention is directed to phenylamide and pyridylamide derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta- secretase enzyme is involved.
L'invention porte sur des composés dérivant de la phénylamide et de la pyridylamide, inhibiteurs de la bêta-secrétase, et s'avérant utiles dans le traitement de maladies telles que celle d'Alzheimer où la bêta-secrétase est impliquée. L'invention porte également sur des préparations pharmaceutiques comprenant ces composés et leur utilisation, et sur des préparations traitant de telles maladies.
Barrow James C.
Coburn Craig A.
Davis Jennifer R.
Nantermet Philippe G.
Selnick Harold G.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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