Phenylaminopyridines

Details Phenylaminopyridines Phenylaminopyridines

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/44 (2006.01) A61K 31/4965 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2578047

The invention relates to novel substituted 3-phenylamino-5-(3- aminophenyl)pyridines and corresponding pyrazines of formula (I), wherein A is CH, C-lower alkyl or N, R1 represents C(=O)R9, S(=O)2R10, P(=O)(OR11)2, optionally substituted phenyl or optionally substituted heteroaryl, and the other substituents have the meaning described in the specification, processes for the preparation thereof, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of neoplastic diseases and autoimmune diseases, and a method for the treatment of such diseases.

L'invention concerne de nouveaux 3-phénylamino-5-(3-aminophényl)pyridines substitués et les pyrazines correspondantes ayant la formule (I) où A représente CH, alkyle inférieur-C ou N, R1 représente C(=O)R9, S(=O)2R10, P(=O)(OR11)2, phényle éventuellement substitué ou hétéroaryle éventuellement substitué, les autres substituants ayant la signification donnée dans la description de la spécification. L'invention concerne également les procédés de cette préparation, les compositions pharmaceutiques les contenant, leur utilisation éventuellement en association avec au moins un autre composé pharmaceutiquement actif pour le traitement de maladies néoplastiques et maladies auto-immunes, et un procédé de traitement de ces maladies.

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