Phenylaminopyrimidines and their use as rho-kinase inhibitors

Details Phenylaminopyrimidines and their use as rho-kinase inhibitors Phenylaminopyrimidines and their use as rho-kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61P 9/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 265/00 (2006.01) C07D 317/00 (2006.01) C07D 401/12 (2006.01) C07D 405/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/10 (2006.01) C07D 498/04 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2489452

The invention relates to phenylaminopyrimidines and processes for their preparation, and to their use for preparing pharmaceuticals for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases. In a specific embodiment, the invention relates to a compound of the formula (see formula I), in which R1 represents amino or hydroxyl, R2 represents hydrogen, (C1-C6)-alkyl or (C3-C8)-cycloalkyl, R3 and R4 independently of one another represent cyano, hydrogen, fluorine or chlorine, A represents a radical (see formula II), (see formula III) or (see formula IV) in which R5 and R6 independently of one another represent hydrogen, fluorine or chlorine, D (1) represents a radical selected from the group consisting of phenyl, etc; quinoline, etc; pyridylmethyl, etc; pyridyl, etc; etc or a salt, hydrate, hydrate of the salt or solvate thereof.

L'invention concerne des phénylaminopyrimidines de formule (I) et leurs procédés de production. Dans ladite formule (I), A, D, R1, R?2¿, R3 et R?4¿ ont la signification donnée dans la description. L'invention concerne également leur utilisation pour produire des médicaments servant au traitement et/ou à la prophylaxie de maladies, en particulier de maladies cardio-vasculaires.

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