Phenylazole compounds, production process and antioxidants

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 405/12 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61P 9/10 (2006.01) A61P 39/06 (2006.01)

Patent

CA 2534263

Compounds represented by the general formula (1) or pharmaceutically acceptable salts thereof; and antioxidants, remedies for kidney diseases or cerebrovascular disorder, or retinal oxidative damage inhibitors, containing the compounds as the active ingredient: B - D - Z (1) wherein B is a group represented by the following general formula (B-1), (B-2), or (B-3): A is optionally substituted imidazolyl or pyrazolyl; E is a group represented by the general formula (1a) or the like: (1a) X is O, SOu, or N-R9; Y is carbon or nitrogen; D is oxygen, sulfur, or a group of the general formula (1a); Z is an NHR10- or OR11-substituted, chroman-2-yl, chroman-4-yl, 2,3-dihydro- benzofuran-2-yl, or 2,3-dihydrobenzofuran-3-yl group or the like.

L'invention concerne des composés représentés par la formule générale (1) ou leurs sels pharmaceutiquement acceptables ainsi que des antioxydants, des remèdes contre les maladies du foie ou les troubles cérébrovasculaires, ou des inhibiteurs de détérioration rétinienne oxydative contenant les composés en tant que principes actifs : (1) B D Z où B est un groupe représenté par la formule générale suivante (B-1), (B-2) ou (B-3), A représente imidazolyle ou pyrazolyle ; E est un groupe représenté par la formule générale (1a) ou analogue : X représente O, SOu ou N-R¿9 ?; Y représente carbone ou azote ; D représente oxygène, soufre ou un groupe de la formule générale (1a) ; Z représente un groupe chroman-2-yle, chroman-4-yle, 2,3-dihydrobenzofuran-2-yle ou 2,3-dihydrobenzofuran-3-yle à substitution NHR¿10? ou OR¿11?.

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