Phenylcarboxyl acid amides and ikr channel inhibitors...

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01) A61P 9/06 (2006.01)

Patent

CA 2519002

The invention relates to a combination of one or several IKr channel inhibitors and one or several Kv1.5 inhibitors, in particular phenylcarboxyl acid amides represented by the formula (Ia) and/or (Ib), and/or acceptable pharmaceutical salts thereof and to the use of the inventive combination for treating atrial arrhythmia.

L'invention concerne l'association d'un ou de plusieurs inhibiteurs du canal IK¿r? et d'un ou de plusieurs inhibiteurs de Kv1.5, en particulier d'amides de l'acide phénylcarboxylique représentés par la formule (Ia) et/ou (Ib), et/ou de sels pharmaceutiquement acceptables de ceux-ci, ainsi que l'utilisation de cette association pour traiter des arythmies atriales.

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