Phenylpentadienoyl derivatives and their use as par 1...

Details Phenylpentadienoyl derivatives and their use as par 1... Phenylpentadienoyl derivatives and their use as par 1...

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/496 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) C07D 213/61 (2006.01) C07D 295/10 (2006.01) C07D 333/36 (2006.01)

Patent

CA 2655728

The present invention relates to compounds of general formula (I): wherein: R1 and R2, identical or different, represent: an atom of hydrogen or halogen, CN or NO2, with R1 and R2 not representing hydrogen simultaneously, m represents: 1 or 2 n represents: 0, 1 or 2 R3 represents: phenyl substituted or not by one or more residues chosen among halogen, hydroxyl or C1-C6 alkyl; C2-C6 alkyl substituted or not by one or more residues chosen among halogen or hydroxyl; cycloalkyl; pyridine; thiophene; pyrrole substituted or not by C1-C6 alkyl; thiazole or furan; or the therapeutically-acceptable salts or solvates thereof.

L'invention concerne des composés représentés par la formule (I) dans laquelle: R1 et R2, qu'ils soient identiques ou différents, représentent: un atome d'hydrogène ou d'halogène, CN ou NO2, R1 et R2 ne représentant pas un atome d'hydrogène simultanément, m représente: 1 ou 2, n représente: 0, 1 ou 2, R3 représente: phényle substitué ou non par un ou plusieurs résidus choisis parmi halogène, hydroxyle ou C1-C6 alkyle; C2-C6 alkyle substitué ou non par un ou plusieurs résidus choisis entre halogène ou hydroxyle; cycloalkyle; pyridine; thiophène; pyrrole substitué ou non par C1-C6 alkyle; thiazole ou furane; ou les solvates ou sels thérapeutiquement acceptables de ceux-ci-

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