Phenylpiperazine derivatives and their acid addition salts

Details Phenylpiperazine derivatives and their acid addition salts Phenylpiperazine derivatives and their acid addition salts

C - Chemistry, Metallurgy

07

D

167/211, 260/254

C07D 403/06 (2006.01) C07D 239/96 (2006.01) C07D 285/32 (2006.01) C07D 417/06 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1287051

TITLE OF THE INVENTION: PHENYLPIPERAZINE DERIVATIVES AND THEIR ACID ADDITION SALTS ABSTRACT OF THE DISCLOSURE: A phenylpiperazine derivative according to the present invention has the following general formula [I]: Image [I] wherein R1, R2 and R3 are independently hydrogen or alkoxy group having 1 to 3 carbon atoms, or R1 and R2 or R2 and R3 together with carbon atoms to which they are attached form -O(CH2)mO- wherein m is an integer of 1 to 3, or either R1 or R2 is amine residue selected from the group consisting of NH2, -NHSO2CH3, -NHCOCH3 and -NHCONH2 and the other is hydrogen or alkoxy group of 1 to 3 carbon atoms and R3 is hydrogen; R4 and R5 are independently hydrogen or alkyl group of 1 to 3 carbon atoms; Y is -CO- or -SO2- provided that at least one of R1 and R2 is not hydrogen when Y is -CO-; and n is an integer of 2 to 4. An acid addition salt of the phenylpiperazine derivative having the general formula [I] is included in the present invention. The phenylpiperazine derivative as well as its acid addition salt according to the present invention have the ability to reduce the blood pressure.

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